Empowering individuals to live their healthiest lives by unlocking their unique biology.

… no two people respond to foods alike. What causes one person’s blood sugar to spike could cause another’s to stabilize. ¹

Professors Elinav and Segal discovered that there was no one “right” diet. In order to best regulate blood sugar, each person needed a diet customized for their particular biology. The implications were huge– could it be that by tapping into the uniqueness of the microbial landscape, it was possible to create a diet that would do exactly that?

This was the landmark research that catalyzed the formation of DayTwo in 2015. As a dietitian herself, co-founder Lihi Segal was familiar with the limitations of traditional one-size-fits-all approaches to diabetes. She saw the enormous potential in bringing a truly personalized, microbiome-based health solution into the market–– a nutritional approach that didn’t only focus on foods, but on the unique makeup of the person eating them.

Building off of the success of their studies, Professors Elinav and Segal went on to employ machine learning to understand how much the existence or absence of certain bacteria in the gut microbiome could impact value predictions, starting with hemoglobin A1C, a commonly used measure to indicate the progression of diabetes and prediabetes. Matching these values with an algorithm that also looked at factors of lifestyle, genetics, anthropometrics (like height and weight), and clinical data, the team developed an algorithm that was able predict blood sugar response in advance of eating. Their study concluded that AI-personalized diets could indeed successfully modify blood glucose response and metabolic impact.

‍

Almost 10 years and numerous clinical studies later (including with the Mayo Clinic) , DayTwo’s precision health approach has helped thousands of people with diabetes reduce medications, avoid surgery, and lower their stress. Given an app that helps them use AI-powered food recommendations and the ability to search over 1 million food, grocery, and restaurant menu items, members can use food as medicine, learning exactly how to tweak their meals in order to keep their blood sugar from spiking. Not only does this cut out the stressful guesswork of making food choices, but it allows members to continue eating meals that are part of their lives and cultures.

The DayTwo program stands out in comparison to other diabetes programs, which typically focus on monitoring, one-size-fits-all and/or carb elimination diets. With virtual care provided by Registered Dietitians and health guides, members receive ongoing support with changing their dietary habits, making it easier for them to stick with the program. Additionally, DayTwo has been cited by the American Diabetes Association (ADA) and National Institutes of Health (NIH) for setting a new national benchmark. According to a report published in Diabetes Care, our program outperformed the traditionally recommended Mediterranean diet in a head-to-head comparison.

DayTwo’s team of scientists, engineers, and researchers has continued to use our proprietary combination of microbiome samples and rich anthropometric inputs to innovate within the realm of precision health. We are utilizing our Microbiome Discovery Platform to train machine learning models to recognize microbiome patterns in order to assess the likelihood of developing certain health conditions. This has huge implications for addressing chronic diseases like cancer, hypertension, and cardiovascular disease, which are amongst the most pervasive in the U.S. and beyond.

At DayTwo, we are excited to continue developing groundbreaking clinical discoveries that allow for a proactive, personalized approach to some of the world’s toughest and most costly conditions. We look forward to partnering with you to help your populations improve their health–– with precise insights based on their own biology.